Systematic review of randomised controlled trials: probiotics for functional constipation.

Anna Chmielewska, Hania Szajewska

Systematic Review World journal of gastroenterology 2010 276 件の引用

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Study Design

研究タイプ: Systematic Review
サンプルサイズ: 377
対象集団: None

介入: Systematic review of randomised controlled trials: probiotics for functional constipation. None
比較対照: control group
主要アウトカム: None
効果の方向: Positive
バイアスリスク: Low

Abstract

AIM: To systematically evaluate and update evidence on the efficacy and safety of probiotic supplementation for the treatment of constipation. METHODS: The MEDLINE, EMBASE, CINAHL, and Cochrane Library databases were searched in May 2009 for randomised controlled trials (RCTs) performed in paediatric or adult populations related to the study aim. RESULTS: We included five RCTs with a total of 377 subjects (194 in the experimental group and 183 in the control group). The participants were adults (three RCTs, n = 266) and children (two RCTs, n = 111) with constipation. In adults, data suggests a favourable effect of treatment with Bifidobacterium lactis DN-173 010, Lactobacillus casei Shirota, and Escherichia coli Nissle 1917 on defecation frequency and stool consistency. In children, L. casei rhamnosus Lcr35, but not L. rhamnosus GG, showed a beneficial effect. CONCLUSION: Until more data are available, we believe the use of probiotics for the treatment of constipation condition should be considered investigational.

要約

Until more data are available, it is believed the use of probiotics for the treatment of constipation condition should be considered investigational.

Used In Evidence Reviews

B Bifidobacterium lactis ： Chronic Constipation

Systematic review of randomised controlled trials: probiotics for functional constipation.

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Study Design

Abstract

要約

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