Faecalibacterium prausnitzii and Crohn's disease - is there any connection?

Mirosława Gałecka, Patrycja Szachta, Anna Bartnicka, Liliana Łykowska-Szuber, Piotr Eder et al.

Other Polish journal of microbiology 2013

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Study Design

Jenis Studi: Observational Study
Ukuran Sampel: 34
Populasi: Patients with Crohn's disease

Intervensi: Faecalibacterium prausnitzii and Crohn's disease - is there any connection? None
Pembanding: None
Luaran Utama: F. prausnitzii levels and SCFA in Crohn's disease
Arah Efek: Negative
Risiko Bias: Unclear

Abstract

The aim of the study was evaluation of the correlation between the level of clinical activity of Crohn's disease (CD) and the number of Faecalibacterium prausnitzii, total number of bacteria and the concentration of selected short chain fatty acids (SCFA) in stool. 34 individuals diagnosed with Crohn's disease participated in this study in 2011. The disease activity was determined according to the Crohn Disease Activity Index (CDAI). The number of Faecalibacterium prausnitzii and total number of bacteria were monitored by RT-PCR. The concentrations of SCFA were determined by gas chromatography. In CD patients, Faecalibacterium prausnitzii number and percentage of the total number of bacteria were greatly reduced. In patients with CD the percentage of acetate was elevated (70%), while the percentages of propionate and butyrate were significantly reduced (14.9% and 7.99%, respectively).

Used In Evidence Reviews

C Butyrate (Sodium/Calcium Butyrate) untuk Crohn's Disease

Faecalibacterium prausnitzii and Crohn's disease - is there any connection?

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Study Design

Abstract

Used In Evidence Reviews

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