What is the recommended dosage for Zinc Carnosine?

General: 75 mg twice daily (as zinc carnosine complex); Nsaid Protection: 37.5-75 mg twice daily alongside NSAID therapy; Gastric Protection: 75 mg twice daily for 8 weeks

What are the side effects of Zinc Carnosine?

Potential side effects include: Nausea (most common, usually transient), Metallic taste, Copper depletion with long-term high-dose use (>40 mg elemental zinc/day), Headache.

What is zinc carnosine and how does it work for gut health?

Zinc carnosine (also known as zinc-L-carnosine or polaprezinc) is a chelated compound of zinc and the dipeptide L-carnosine. This unique molecular complex adheres to the stomach lining and provides localized protection and healing. Research suggests it may help protect against NSAID-induced gut damage, support gastric mucosal repair, and reduce intestinal permeability. It has been approved as a prescription drug for gastric ulcers in Japan since 1994.

What is the recommended dosage of zinc carnosine?

The standard dosage used in clinical studies and the Japanese prescription formulation is 75 mg of zinc carnosine (providing approximately 16 mg of elemental zinc) taken twice daily, typically before meals. This dosage has been consistently used in studies showing benefits for gastric mucosal protection and intestinal permeability. Treatment duration in studies is typically 4-8 weeks.

Are there side effects or interactions with zinc carnosine?

Zinc carnosine is well-tolerated with minimal side effects in clinical trials. It provides a moderate amount of zinc, so long-term use should account for total zinc intake to avoid copper depletion. It may interact with antibiotics and bisphosphonates. The carnosine component is generally recognized as safe. Individuals already taking zinc supplements should adjust their total zinc intake accordingly.

Zinc Carnosine
Zinc Carnosine

mineral

Aussi connu sous le nom de: ZnC, Zinc-L-Carnosine, Polaprezinc, PepZin GI

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About

Zinc carnosine (ZnC) is a chelated complex of zinc and L-carnosine with unique gastro-protective properties. Unlike other zinc forms, it preferentially adheres to ulcerated gastric tissue and may help stabilize cell membranes and induce heat shock protein expression. Research suggests it may reduce NSAID-induced small bowel injury by up to 70% as measured by calprotectin, and support gastric mucosal healing.

How It Works

Chelated zinc-L-carnosine complex that preferentially adheres to ulcerated gastric tissue; stabilizes cell membranes against acid-pepsin injury; induces heat shock protein (HSP70) expression protecting against mucosal damage; suppresses H. pylori growth; reduces NSAID-induced intestinal permeability by blocking inflammatory cytokine cascades.

Evidence For Conditions

Pathologie	Note	Études	Participants
Peptic Ulcer Disease	B	6	500	Voir →
Increased Intestinal Permeability (Leaky Gut)	C	2	100	Voir →

Side Effects

Nausea (most common, usually transient)
Metallic taste
Copper depletion with long-term high-dose use (>40 mg elemental zinc/day)
Headache

Drug & Supplement Interactions

Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
Penicillamine (zinc reduces absorption)
Copper supplements (zinc competes with copper for absorption)
Bisphosphonates (zinc may reduce absorption; space 2 hours)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Zinc

En bref

Posologie: General: 75 mg twice daily (as zinc carnosine complex); Nsaid_Protection: 37.5-75 mg twice daily alongside NSAID therapy; Gastric_Protection: 75 mg twice daily for 8 weeks
Formes: capsule tablet
Sources naturelles: Not found naturally (synthetic chelate), Zinc found in: oysters, beef, pumpkin seeds, lentils, Carnosine found in: beef, chicken, pork, fish
Limite supérieure: 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this
Meilleur moment: On an empty stomach or between meals for gastric mucosal contact; twice daily

Synthèse des preuves

Peptic Ulcer Disease B

Increased Intestinal Permeability (Leaky Gut) C

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.