What is the recommended dosage for Deglycyrrhizinated Licorice (DGL)?

General: 380-760 mg DGL extract 3 times daily before meals; Gastric Support: 760 mg before meals and at bedtime; Dyspepsia Support: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily

What are the side effects of Deglycyrrhizinated Licorice (DGL)?

Potential side effects include: Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product).

What is deglycyrrhizinated licorice (DGL) and how does it work for gut health?

DGL is a processed form of licorice root with glycyrrhizin removed to prevent side effects like elevated blood pressure. It may help protect the stomach and esophageal lining by stimulating mucus production and promoting the growth of protective mucosal cells. Research suggests DGL may support healing of the gastric lining and help manage symptoms of heartburn and indigestion.

What is the recommended dosage of DGL?

The typical dosage is 380-760 mg of DGL taken 20 minutes before meals, 2-3 times daily. Chewable tablets are traditionally preferred as the act of chewing may stimulate salivary epidermal growth factor, which can further support mucosal healing. Some clinicians recommend taking DGL for 8-16 weeks for optimal results.

Are there side effects or interactions with DGL?

Because glycyrrhizin has been removed, DGL is significantly safer than whole licorice root and does not typically cause hypertension or potassium depletion. Side effects are rare and mild. However, individuals should verify that their DGL product has been properly deglycyrrhizinated. DGL may interact with certain medications, so consulting a healthcare provider is still recommended.

Deglycyrrhizinated Licorice (DGL)
Deglycyrrhizinated Licorice (DGL)

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Aussi connu sous le nom de: DGL, Deglycyrrhizinated Glycyrrhiza glabra, GutGard, DGL Licorice

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About

Deglycyrrhizinated licorice (DGL) is a specially processed form of licorice root with the glycyrrhizin compound removed to prevent aldosterone-like side effects (hypertension, hypokalemia). DGL may help stimulate mucus and bicarbonate secretion in the gastric lining and enhance prostaglandin E2 production, which supports mucosal integrity. Research suggests it may support digestive comfort in functional dyspepsia and provide protective support for the gastric lining.

How It Works

Stimulates mucus and bicarbonate secretion in the gastric lining strengthening the mucosal defense barrier; enhances prostaglandin E2 production protecting mucosal integrity; promotes epithelial cell proliferation supporting mucosal repair; glycyrrhizin removed to prevent mineralocorticoid side effects.

Evidence For Conditions

Pathologie	Note	Études	Participants
Functional Dyspepsia	C	3	200	Voir →
Peptic Ulcer Disease	C	2	150	Voir →

Side Effects

Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
Mild nausea in rare cases
Headache (uncommon)
If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)

Drug & Supplement Interactions

Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
Diuretics (if residual glycyrrhizin, additive potassium loss)
Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Curcumin Peppermint Oil Ginger Berberine Slippery Elm

En bref

Posologie: General: 380-760 mg DGL extract 3 times daily before meals; Gastric_Support: 760 mg before meals and at bedtime; Dyspepsia_Support: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily
Formes: chewable tablet (preferred) capsule powder liquid extract
Sources naturelles: Licorice root (Glycyrrhiza glabra) — processed to remove glycyrrhizin
Limite supérieure: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
Meilleur moment: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact

Synthèse des preuves

Functional Dyspepsia C

Peptic Ulcer Disease C

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.