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Pooled effect sizes from animal studies indicate that berry-derived polyphenols are associated with significant changes in inflammatory cytokine expression (TNF-α) relative to control groups. Heterogeneity across the included studies suggests variability in dosing protocols and animal models.

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![Figure 463: Pooled effect sizes from animal studies indicate that berry-derived polyphenols are associated with significant changes in inflammatory cytokine expression (TNF-α) relative to control groups. Heterogeneity across the included studies suggests variability in dosing protocols and animal models.]()

> Source: Leila Khalili et al. "Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gu." *International journal of molecular sciences*, 2023. PMID: [36834497](https://pubmed.ncbi.nlm.nih.gov/36834497/)
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  <img src="" alt="Pooled effect sizes from animal studies indicate that berry-derived polyphenols are associated with significant changes in inflammatory cytokine expression (TNF-α) relative to control groups. Heterogeneity across the included studies suggests variability in dosing protocols and animal models." />
  <figcaption>Figure 463. Pooled effect sizes from animal studies indicate that berry-derived polyphenols are associated with significant changes in inflammatory cytokine expression (TNF-α) relative to control groups. Heterogeneity across the included studies suggests variability in dosing protocols and animal models.<br>  Source: Leila Khalili et al. "Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gu." <em>International journal of molecular sciences</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36834497/">36834497</a></figcaption>
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