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Figure 5

Description

Animal models of colitis demonstrate that vitamin D deficiency exacerbates intestinal inflammation, while supplementation or VDR activation attenuates disease severity. These findings support a mechanistic link between vitamin D status and IBD pathophysiology.

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Vitamin D receptor expression and vitamin D-activating enzyme CYP27B1 are present in human colonic epithelial cells, enabling local production of active calcitriol. This paracrine signaling enhances tight junction integrity and antimicrobial defense at the mucosal surface.

Figure 6

Vitamin D receptor expression and vitamin D-activating enzyme CYP27B1 are present in human colonic epithelial cells, enabling local production of active calcitriol. This paracrine signaling enhances tight junction integrity and antimicrobial defense at the mucosal surface.

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Figure 5

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Source Paper

The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management.

Nutrients (2019)

PMID: 31067701

DOI: 10.3390/nu11051019

Cite This Figure

![Figure 5: Animal models of colitis demonstrate that vitamin D deficiency exacerbates intestinal inflammation, while supplementation or VDR activation attenuates disease severity. These findings support a mechanistic link between vitamin D status and IBD pathophysiology.](https://pdfs.citedhealth.com/figures/31067701/109.png)

> Source: Jane Fletcher et al. "The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management.." *Nutrients*, 2019. PMID: [31067701](https://pubmed.ncbi.nlm.nih.gov/31067701/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/31067701/109.png" alt="Animal models of colitis demonstrate that vitamin D deficiency exacerbates intestinal inflammation, while supplementation or VDR activation attenuates disease severity. These findings support a mechanistic link between vitamin D status and IBD pathophysiology." />
  <figcaption>Figure 5. Animal models of colitis demonstrate that vitamin D deficiency exacerbates intestinal inflammation, while supplementation or VDR activation attenuates disease severity. These findings support a mechanistic link between vitamin D status and IBD pathophysiology.<br>  Source: Jane Fletcher et al. "The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management.." <em>Nutrients</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31067701/">31067701</a></figcaption>
</figure>

Related Evidence

B
Vitamin D for Inflammatory Bowel Disease (IBD) — General

Grade B · 10 studies