Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome.

Qiao-Yan Gu, Jun Zhang, Yi-Chao Feng

Other Artificial cells, nanomedicine, and biotechnology 2016 16 Zitierungen

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Study Design

Studientyp: Other
Stichprobengröße: 10
Population: IBS patients

Intervention: Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome. None
Vergleichsgruppe: control
Primärer Endpunkt: None
Wirkungsrichtung: Positive
Verzerrungsrisiko: Unclear

Abstract

We aimed to explore the role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome (PI-IBS). Fifty NIH mice were divided into five groups (n = 10). The visceral sensitivities of PI-2W and PI-8W groups significantly exceeded than those of normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Significantly more IL-18 and IL-1β were expressed in PI-2W and PI-8W groups than those in normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Bifidobacterium longum may down-regulate IL-18 and IL-1β expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.

Zusammenfassung

Bifidobacterium longum may down-regulate IL-18 and IL-1β expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.

Used In Evidence Reviews

B Bifidobacterium longum für Irritable Bowel Syndrome (IBS)

Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome.

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Study Design

Abstract

Zusammenfassung

Used In Evidence Reviews

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