Faecalibacterium prausnitzii and Crohn's disease - is there any connection?

Mirosława Gałecka, Patrycja Szachta, Anna Bartnicka, Liliana Łykowska-Szuber, Piotr Eder et al.

Other Polish journal of microbiology 2013

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'pmid\u003D23829084'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Study Design

Studientyp: Observational Study
Stichprobengröße: 34
Population: Patients with Crohn's disease

Intervention: Faecalibacterium prausnitzii and Crohn's disease - is there any connection? None
Vergleichsgruppe: None
Primärer Endpunkt: F. prausnitzii levels and SCFA in Crohn's disease
Wirkungsrichtung: Negative
Verzerrungsrisiko: Unclear

Abstract

The aim of the study was evaluation of the correlation between the level of clinical activity of Crohn's disease (CD) and the number of Faecalibacterium prausnitzii, total number of bacteria and the concentration of selected short chain fatty acids (SCFA) in stool. 34 individuals diagnosed with Crohn's disease participated in this study in 2011. The disease activity was determined according to the Crohn Disease Activity Index (CDAI). The number of Faecalibacterium prausnitzii and total number of bacteria were monitored by RT-PCR. The concentrations of SCFA were determined by gas chromatography. In CD patients, Faecalibacterium prausnitzii number and percentage of the total number of bacteria were greatly reduced. In patients with CD the percentage of acetate was elevated (70%), while the percentages of propionate and butyrate were significantly reduced (14.9% and 7.99%, respectively).

Used In Evidence Reviews

C Butyrate (Sodium/Calcium Butyrate) für Crohn's Disease

Faecalibacterium prausnitzii and Crohn's disease - is there any connection?

Embed This Widget

Study Design

Abstract

Used In Evidence Reviews

Similar Papers

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis.

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives.

Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation.

Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease.