**Figure 6.** Figure 1. Inﬂammatory bowel diseases (IBD), activation of the nuclear factor-kB (NF-kB), and the possible roles of phytochemicals against this pathway activation during these diseases. ↑, increase; TLRs, Toll-like receptors; IKKα, IkappaB kinase alfa; IKKβ, IkappaB kinase beta; IKB, inhibitor of nuclear factor-kB.

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Inflammatory bowel diseases are associated with activation of the NF-kB signaling pathway. This diagram illustrates how various phytochemicals may counteract NF-kB pathway activation through inhibition of Toll-like receptors, IKK complex, and downstream transcriptional targets in IBD.

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Figure 218

Supplementary figure from a comprehensive review of phytochemical effects on NF-kB regulation in inflammatory bowel disease. The review examines multiple plant-derived compounds with potential to attenuate chronic intestinal inflammation through modulation of key signaling pathways.

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Figure 6

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Source Paper

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects.

Metabolites (2023)

PMID: 36677021

DOI: 10.3390/metabo13010096

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![Figure 6: Inflammatory bowel diseases are associated with activation of the NF-kB signaling pathway. This diagram illustrates how various phytochemicals may counteract NF-kB pathway activation through inhibition of Toll-like receptors, IKK complex, and downstream transcriptional targets in IBD.](https://pdfs.citedhealth.com/figures/36677021/176.png)

> Source: Lucas Fornari Laurindo et al. "Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overvi." *Metabolites*, 2023. PMID: [36677021](https://pubmed.ncbi.nlm.nih.gov/36677021/)

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  <img src="https://pdfs.citedhealth.com/figures/36677021/176.png" alt="Inflammatory bowel diseases are associated with activation of the NF-kB signaling pathway. This diagram illustrates how various phytochemicals may counteract NF-kB pathway activation through inhibition of Toll-like receptors, IKK complex, and downstream transcriptional targets in IBD." />
  <figcaption>Figure 6. Inflammatory bowel diseases are associated with activation of the NF-kB signaling pathway. This diagram illustrates how various phytochemicals may counteract NF-kB pathway activation through inhibition of Toll-like receptors, IKK complex, and downstream transcriptional targets in IBD.<br>  Source: Lucas Fornari Laurindo et al. "Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overvi." <em>Metabolites</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36677021/">36677021</a></figcaption>
</figure>

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