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Study design and participant flow for the double-blind, randomized, placebo-controlled trial of Lactobacillus plantarum CCFM1143 in chronic diarrhea are presented. The trial evaluated the probiotic's effects on inflammation regulation and gut microbiota modulation in patients with IBS-D or functional diarrhea.

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![Figure 1: Study design and participant flow for the double-blind, randomized, placebo-controlled trial of Lactobacillus plantarum CCFM1143 in chronic diarrhea are presented. The trial evaluated the probiotic's effects on inflammation regulation and gut microbiota modulation in patients with IBS-D or functional diarrhea.]()

> Source: Bo Yang et al. "Lactobacillus plantarum CCFM1143 Alleviates Chronic Diarrhea via Inflammation Re." *Frontiers in immunology*, 2021. PMID: [34721416](https://pubmed.ncbi.nlm.nih.gov/34721416/)
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  <img src="" alt="Study design and participant flow for the double-blind, randomized, placebo-controlled trial of Lactobacillus plantarum CCFM1143 in chronic diarrhea are presented. The trial evaluated the probiotic's effects on inflammation regulation and gut microbiota modulation in patients with IBS-D or functional diarrhea." />
  <figcaption>Figure 1. Study design and participant flow for the double-blind, randomized, placebo-controlled trial of Lactobacillus plantarum CCFM1143 in chronic diarrhea are presented. The trial evaluated the probiotic's effects on inflammation regulation and gut microbiota modulation in patients with IBS-D or functional diarrhea.<br>  Source: Bo Yang et al. "Lactobacillus plantarum CCFM1143 Alleviates Chronic Diarrhea via Inflammation Re." <em>Frontiers in immunology</em>, 2021. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/34721416/">34721416</a></figcaption>
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