**Figure 6.** Figure 2. The n-3 polyunsaturated fatty acid targets of intestinal innate immunity. ALA, α-linolenic acid; CARD, caspase recognition domain; COX, cyclooxygenase; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; GPR, G-protein coupled receptor; ICAM, intracellular adhesion molecule; IL, interleukin; iNOS, inducible nitric oxide synthase; MAPK, mitogen-activated protein kinase; MMPs, matrix metalloproteinase; NF-κB, nuclear factor kB; NLRP3, NOD-like receptor protein 3; NOD2, nucleotide-binding oligomerisation domain 2; PGN, bacterial peptidoglycan; PPAR-γ, peroxisome proliferator-activated receptor γ; RXR, retinoid X receptor; TLR, toll-like receptor; TNFα, tumour necrosis factor α.

Beschreibung

N-3 polyunsaturated fatty acids modulate intestinal innate immunity through multiple receptor and signaling targets. This diagram maps the interactions of DHA and EPA with G-protein coupled receptors, COX enzymes, and caspase recognition domains in intestinal immune cells.

More Figures from This Paper

Figure 5

N-3 and n-6 polyunsaturated fatty acids follow distinct biosynthetic pathways to produce eicosanoids and specialized pro-resolving mediators. This diagram outlines the synthesis routes from alpha-linolenic acid and arachidonic acid through COX and cytochrome P450 enzymes to their bioactive lipid products.

diagram

Figure 7

Current IBD treatments employ both immuno-suppressive and immuno-resolving strategies. This diagram contrasts conventional therapies (azathioprine, anti-TNF agents) with emerging PUFA-based approaches that promote active resolution of intestinal inflammation.

diagram

Figure 6

Diagram

643 × 488px · 287,6 KB

Source Paper

The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives.

International journal of molecular sciences (2017)

PMID: 29206211

DOI: 10.3390/ijms18122619

Cite This Figure

![Figure 6: N-3 polyunsaturated fatty acids modulate intestinal innate immunity through multiple receptor and signaling targets. This diagram maps the interactions of DHA and EPA with G-protein coupled receptors, COX enzymes, and caspase recognition domains in intestinal immune cells.](https://pdfs.citedhealth.com/figures/29206211/182.png)

> Source: Eleonora Scaioli et al. "The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel." *International journal of molecular sciences*, 2017. PMID: [29206211](https://pubmed.ncbi.nlm.nih.gov/29206211/)

<figure>
  <img src="https://pdfs.citedhealth.com/figures/29206211/182.png" alt="N-3 polyunsaturated fatty acids modulate intestinal innate immunity through multiple receptor and signaling targets. This diagram maps the interactions of DHA and EPA with G-protein coupled receptors, COX enzymes, and caspase recognition domains in intestinal immune cells." />
  <figcaption>Figure 6. N-3 polyunsaturated fatty acids modulate intestinal innate immunity through multiple receptor and signaling targets. This diagram maps the interactions of DHA and EPA with G-protein coupled receptors, COX enzymes, and caspase recognition domains in intestinal immune cells.<br>  Source: Eleonora Scaioli et al. "The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel." <em>International journal of molecular sciences</em>, 2017. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29206211/">29206211</a></figcaption>
</figure>

Beschreibung

More Figures from This Paper

Figure 6

Source Paper

Cite This Figure

Verwandte Evidenz