Lactobacillus casei für Antibiotic-Associated Diarrhea (AAD)

Some evidence for AAD prevention in hospitalized elderly patients (PLACIDE trial was negative for primary outcome but showed trends).

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Fazit

Some evidence for AAD prevention in hospitalized elderly patients (PLACIDE trial was negative for primary outcome but showed trends).

Key Study Findings

In Vitro

Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice.

Dose: 4-strain probiotic mixture vs.: Ampicillin-induced AAD model Outcome: Gut microbiota recovery and immune modulation Wirkung: None None

Population: Ampicillin-induced AAD mouse model

Meta-Analysis n=692

Which probiotic has the best effect on preventing Clostridium difficile-associated diarrhea? A systematic review and …

Dose: None vs.: Control group Outcome: the incidence rates of AAD and CDAD, and … Wirkung: OR 0.39, None

Population: Diarrhea patients

Randomized Controlled Trial n=314 4.3 weeks Double-blind

Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial.

Dose: None vs.: Placebo Outcome: Bowel function Wirkung: None p=0.30

Population: None

Systematic Review n=228

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis.

Dose: None vs.: None Outcome: Diarrhea outcomes Wirkung: None None

Population: None

Controlled Clinical Trial n=32 4.3 weeks Open-label

Feasibility of a Lactobacillus casei Drink in the Intensive Care Unit for Prevention of Antibiotic …

Dose: 10 billion L. casei, 2 bottles/day vs.: Contemporary matched controls Outcome: Safety, feasibility, AAD incidence Wirkung: None None

Population: ICU patients on antibiotics

Meta-Analysis n=9569

Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis.

Dose: None vs.: Placebo/no probiotic Outcome: Prevention of antibiotic-associated diarrhea Wirkung: LGG OR 0.28 (0.17-0.47) for AAD prevention None

Population: Patients on antibiotics

Key Statistics

Studien

500

Teilnehmer

↑

Positive

Bewertung

Referenced Papers

Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice. Other

Frontiers in microbiology 2023 21 Zitierungen

Which probiotic has the best effect on preventing Clostridium difficile-associated diarrhea? A systematic review and network meta-analysis. Meta-Analysis

Journal of digestive … 2020 43 Zitierungen

Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial. RCT

Journal of clinical … 2019 17 Zitierungen

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis. Other

Frontiers in medicine 2018 450 Zitierungen

Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis. Review

United European gastroenterology … 2018 66 Zitierungen

Feasibility of a Lactobacillus casei Drink in the Intensive Care Unit for Prevention of Antibiotic Associated Diarrhea and Clostridium difficile. CCT

Nutrients 2018 50 Zitierungen

Probiotics in critically ill children. Review

F1000Research 2016 63 Zitierungen

Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Review

Antibiotics (Basel, Switzerland) 2015 104 Zitierungen

Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+): Characterization, Manufacture, Mechanisms of Action, and Quality Control of … Review

Clinical infectious diseases … 2015 59 Zitierungen

Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea. RCT

World journal of … 2014 73 Zitierungen

Savings from the use of a probiotic formula in the prophylaxis of antibiotic-associated diarrhea. Other

Journal of medical … 2012 28 Zitierungen

The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial. RCT

Revista da Sociedade … 2012 13 Zitierungen

Probiotics for prevention and treatment of diarrhea. Review

Journal of clinical … 2011 432 Zitierungen

Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium … RCT

The American journal … 2010 313 Zitierungen

Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, … RCT

Canadian journal of … 2007 182 Zitierungen

In vitro antibiotic susceptibility of lactobacilli isolated from commercial products containing active lactobacilli. Other

Acta paediatrica Taiwanica … 2004 6 Zitierungen

Treatment and prevention of antibiotic associated diarrhea. Review

International journal of … 2000 181 Zitierungen

Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. RCT

The Journal of … 1999 559 Zitierungen

Pharmaceutical probiotics for the treatment of anaerobic and other infections. Other

Anaerobe 1997 40 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:: 1-10 billion CFU/day
aadprevention:: 6.5 billion CFU/day (Shirota strain)
immunesupport:: 10 billion CFU/day

Obergrenze: Well-tolerated up to 20 billion CFU/day in clinical trials

In der Forschung untersuchte Dosierungen

Dosierung	Dauer	Wirkung	N
4-strain probiotic mixture	--	Positive	--
None	--	Positive	692
None	4.3 weeks	Neutral	314
None	--	Mixed	228
10 billion L. casei, 2 bottles/day	4.3 weeks	Positive	32
None	--	Positive	9569
None	--	Mixed	--
None	--	Positive	--

Beste Einnahmezeit: With or without food; consistent daily timing recommended

Safety & Side Effects

Gemeldete Nebenwirkungen

⚠ Mild gas and bloating during initial use
⚠ Occasional loose stools
⚠ Rare dairy-related reactions in lactose-sensitive individuals
⚠ Very rare: bacteremia in immunocompromised individuals

Bekannte Wechselwirkungen

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)

Tolerierbare Höchstaufnahmemenge: Well-tolerated up to 20 billion CFU/day in clinical trials

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Lactobacillus casei help with Antibiotic-Associated Diarrhea (AAD)?

Based on 3 studies with 500 participants, there is limited but promising evidence that Lactobacillus casei may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is C (Some Evidence).

How much Lactobacillus casei should I take for Antibiotic-Associated Diarrhea (AAD)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus casei?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare dairy-related reactions in lactose-sensitive individuals, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus casei and Antibiotic-Associated Diarrhea (AAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

Andere Inhaltsstoffe für Antibiotic-Associated Diarrhea (AAD)

Saccharomyces boulardii A Lactobacillus rhamnosus GG A

Kurzfazit

Some evidence for AAD prevention in hospitalized elderly patients (PLACIDE trial was negative for primary outcome but showed trends).

Evidence Strength52%

Moderate confidence

Studienübersicht

RCT (6)Meta (1)Other (0)

Alternativen vergleichen

Sehen Sie, wie andere Inhaltsstoffe bei dieser Beschwerde abschneiden.

Alle Inhaltsstoffe ansehen für Antibiotic-Associated Diarrhea (AAD)

Mehr erfahren

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